Significance of the mathematically calculated red cell indices in patients with qualitative and quantitative hemoglobinopathies

Abstract Background Hemoglobinopathies represent a set of inherited red blood cell (RBCs) disorders, characterized by abnormal hemoglobin molecule. They include qualitative and quantitative hemoglobinopathies, with structurally globin chain in the first defective production later. This study assessed, for time, significance mathematically calculated RBC indices to identify patients hemoglobinopathies from normal subjects or iron deficiency anemia (IDA) differentiate various types each other. Subjects methods The was comparative hospital based included 167 participants (group 1) 49 IDA 2) as an active comparator. Another 50 healthy volunteers 3) were also included. All subjected medical history, clinical examination, CBC, HPLC. Next, 10 CBC participant. Results Gender analysis shows that females 36.8% thalassemia group, 42% sickle disease (SCD) 71.4% group. receiver operating characteristic (ROC) curve Ehsani index (EI) is most reliable screening tool thalassemics because showing highest Youden specificity 41.88% 88.89%, respectively, followed Shine Lal (SL), (YI) value, specificity, sensitivity equal 39.78%, 69.70%, 70.09%, respectively. Similar results found IDA. For SCD, SL suitable tool. In conclusion, are available, cheap, reliable, sensitive tools hemoglobinopathies.